邵慧萍,俞新鼎,张雨梦,杨思明.3D凝胶打印用于松质骨工程的TCP多孔支架的制备[J].稀有金属材料与工程,0,():-.[Shao Huiping,Yu Xinding,Zhang Yumeng,Yang Siming.Preparation of porous TCP scaffolds for cancellous bone engineering by 3D gel-printing[J].Rare Metal Materials and Engineering,0,():-].
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3D凝胶打印用于松质骨工程的TCP多孔支架的制备
投稿时间:2020-06-07  修订日期:2020-06-24
中文关键词:  TCP  多孔支架  3DGP  兔子  松质骨
基金项目:The Key Research and Development Projects of the People’s Liberation Army (BWS17J036)
中文摘要:
      该文通过3D凝胶打印(3DGP)制备高强度和高孔隙率的TCP多孔支架。通过扫描电子显微镜(SEM)观察支架的微观形态,并通过动物实验评估它们的生物相容性。通过研究表明适合打印的浆料固含量设定为34vol%,打印支架在长度、宽度和高度方向上的收缩率分别为11.44±0.20%,9.41±0.23%和10.57±0.20%。当支架在1150℃下烧结2小时后,支架的抗压强度为22.6±0.12MPa,孔隙率约为62.1%。动物植入实验显示多孔TCP支架在兔股骨髁缺损处未引起明显的排斥反应,并且在骨与支架的连接处没有炎症反应或慢性炎症反应。总之,通过3DGP技术制备的多孔TCP支架具有良好的生物相容性和优异的强度,有望满足松质骨的植入要求。
Preparation of porous TCP scaffolds for cancellous bone engineering by 3D gel-printing
英文关键词:TCP  Porous scaffolds  3DGP  Rabbit  Cancellous bone
英文摘要:
      High-strength and high-porosity tricalcium phosphate (TCP) scaffolds were prepared by 3D gel-printing (3DGP) in this study. The microscopic morphology of the scaffolds was observed by scanning electron microscopy (SEM) and their biocompatibility was evaluated by animal experiments. The solid loading of slurry suitable for printing was set as 34 vol%, and the shrinkage of printing scaffolds in length, width and height directions were 11.44±0.20%, 9.41±0.23% and 10.57±0.20%, respectively. When they were sintered at 1150 °C for 2 h, the compressive strength of the scaffolds was 22.6 ± 0.12 MPa and their porosity was about 62.1%. The animal implantation experiment shows porous TCP scaffolds did not cause significant tissue rejection in rabbit femoral condylar defects, and there was no inflammatory reaction or chronic inflammatory reaction at the bone-to-scaffold junction. In conclusion, porous TCP scaffolds prepared by 3DGP technology, which have good biocompatibility and excellent strength, are expected to meet the implantation requirements of cancellous bone.
作者单位
邵慧萍 北京科技大学 新材料技术研究院 
俞新鼎 北京科技大学 新材料技术研究院 
张雨梦 北京科技大学 新材料技术研究院 
杨思明 中国人民解放军总医院 伤口修复与再生重点实验室 
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